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Introduction

About Me...

I am Tianfeng Lu. After graduating from Zhejiang University, now I am continuing my journey in computational biology research at WashU.

The Gateway Arch in St Louis, taken in Neuroscience Research Building (NRB)

The Gateway Arch in St Louis, taken in Neuroscience Research Building (NRB)
What have I learned?

My skills

Computing Science

Data structure and algorithm. Programming in C, Cpp, python, R.

Bioinformatics

Bioinformatics analysis for next-generation sequencing.

Mathematics

Basic courses in analysis and statistics. Expertise in algebra and geometry.

Publications

Publications

P. Dong, Y. Li, Y. Wang, Q. Zhao, T. Lu, T. Guo, J. Ma, B. Yang, H. Wu, H. Huang. Fat body-derived cytokine Upd2 controls disciplined migration of tracheal stem cells in Drosophila. eLife 13:RP100037 (2024).

Y. Li, T. Lu#, P. Dong, J. Chen, Q. Zhao, Y. Wang, T. Xiao, H. Wu, Q. Zhao, and H. Huang. A single-cell atlas of Drosophila trachea reveals glycosylation-mediated Notch signaling in cell fate specification. Nature Communications 15, 2019 (2024).

Y. Li, P. Dong, Y. Yang, T. Guo, Q. Zhao, D. Miao, H. Li, T. Lu, F. Xia, J. Lyu, J. Ma, T. B. Kornberg, Q. Zhang, and H. Huang. Metabolic control of progenitor cell propagation during Drosophila tracheal remodeling. Nature Communications 13, 2817 (2022).

Timeline

My Experience

PhD student at Washington University in St. Louis    August 2024-present

Visiting student at Washington University in St. Louis    August 2023-June 2024

Summer student in IDG/McGovern institute at Tsinghua University    July 2022-May 2023

Undergraduate student at Zhejiang University    August 2019-July 2023

My Work

Recent Projects

Neuronal coordination structure in a visuomotor transformation

We show that, while moving spot visual stimuli drive localized neural coordination in the tectum, the subsequent tail response is coordinated across the whole brain. Most importantly, the global mode dominates the majority of trial-to-trial fluctuations. Our findings reveal a conservative method for the brain to exploit distinct neuronal ensembles when undergoing sensorimotor transformations, and offer a system-level view of the underlying brain-wide neural dynamics.

Data Analysis of Widefield Ca2+ Imaging in General Anesthesia

This work suggested that the rodent brain exhibits distinct statistical property in different consciousness states. Notably, dynamical system analysis revealed that in general anesthesia loss/gain of consciousness is an asymmetric process despite symmetric EEG representation, implying distinct neuronal mechanisms to disconnect/reconnect consciousness-related networks. It is the first time to directly relate brain information processing to invertible loss of consensus transitions based on cortical-wide single-neuronal recordings.

Single cell atlas of fly trachea

Since previous result implies a complicated metabolic network during trachea development, It is intriguing to explore molecular features of fly trachea in single cell resolution to further resolve development landmarks in trachea remodeling.

Cell classification in cardiovascular diseases

A decision tree based model was utilized to make classification for homogenous cell population. The model discovered a BMP signal activated smooth muscle cell population in carotid artery instead of coronary artery and explained why there is a vascular calcification level difference in these tissues.

Collections

Miscellaneous

Reading notes in neuroscience (Chinese), 2021 summer
Mathematical Collections (Chinese)

An introduction to dimension reduction methods in neuroscience (Chinese), invited by Univeron, 2021 winter